Latrunculin B 76343-94-7 | Actin Filament Modulr | impairs ultrafast endocytosis

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Latrunculin B, NSC 339663

L-1057
  • CAS: 76343-94-7
  • Formula: C20H29NO5S
  • MW: 395.5
  • Appearance: Lyophilized Solid
  • Purity: 98%

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Latrunculin B is an actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture.Latrunculin B causes stress fibers toshortening and thicken.EffectsN1E-115 cells (mouse neuroblastoma) at starting concentrationsof 90 nM (NI43T3 cells, 0.9M). Maximumeffect at 2.5M. Fetal Bovine serum will slowly inactivate. Inhibitscofilin-actin binding (ED~50 M).Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent.Differential Involvement of the Actin Cytoskeleton in Differentiation and Mitogenesis of Thyroid Cells: Inactivation of Rho Proteins Contributes to Cyclic Adenosine Monophosphate-Dependent Gene Expression but Prevents Mitogenesis.A Role for Cytoskeletal Elements in the Light-Driven Translocation of Proteins in Rod Photoreceptors.The Potato Virus X TGBp2 Movement Protein Associates with Endoplasmic Reticulum-Derived Vesicles during Virus Infection.

Additional Information

SynonymsLatrunculin B, Actin filament modulator.
Product #L-1057
CAS #76343-94-7
Chemical Name(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-HYDROXY-5,10-DIMETHYL-3-OXO-2,14-DIOXABICYCLO[11.3.1]HEPTADECA-4,8-DIEN-15-YL]-1,3-THIAZOLIDIN-2-ONE
FormulaC20H29NO5S
MW395.5
AppearanceLyophilized Solid
Purity98%
SolubilitySoluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Melting Point258.13 °C
Storage Temp-20°C
UseLatrunculin B is a structurally unique marine toxin

Additional Information

Merck IndexMerck Index: 14: 5378
MDL NumberMFCD00270879
ChemACXX1000493-6
InChIInChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13?,15-,16?,17-,20-/m1/s1
SMILESCC/1CC[C@@H]2CC(C[C@@](O2)([C@H]3CSC(=O)N3)O)OC(=O)/C=C(CC/C=C1)/C

Additional Information

GHS Pictograms
HandlingWarning.Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Store in Tightly Sealed Vial

Additional Information

Certificate of Analysis 1L-1057, G1026.pdf
Certificate of Analysis 2L-1057, E1251.pdf
Certificate of Analysis 3L-1057, D1290A.pdf
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