Lovastatin | CAS 75330-75-5 | HMGCR Inhibitor prevents cardiovascular disease | AG Scientific, Inc.

More Views


  • CAS: 75330-75-5
  • Formula: C24H36O5
  • MW: 404.55 Da
  • Appearance: White solid
  • Purity: ≥98 %




Add to Cart Bulk Inquiry


Lovastatin (also known as mevinolin or MK-803) is a cell-permeable inhibitor of HMG-CoA reductase, MAP kinase, and p21ras activation.


Applications and Effects of Lovastatin

• Used to lower cholesterol levels, particularly “bad” forms such as LDL cholesterol and triglycerides
• Used to reduce the risk of heart disease and heart attacks
• Used in dietary supplements


Additional Information

SynonymsMevinolin, MK-803, 6-a-Methylcompactin, Monacolin K
Product #L-1043
CAS #75330-75-5
Chemical Name6-a-Methylcompactin
MW404.55 Da
AppearanceWhite solid
Purity≥98 %
SolubilitySoluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Melting Point175.4 °C
Storage Temp-20°C
Therapeutic AreaCardiological Disorders, Metabolic Disorders
UseLovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) to reduce risk of cardiovascular disease.

Additional Information

Merck Index13.5608.2001
MDL NumberMFCD00072164

Additional Information

GHS Pictograms
HandlingStore in a tightly-sealed vial. Protect from light and moisture.

Additional Information

Certificate of Analysis 1L-1043, H1179C.pdf
Certificate of Analysis 2L-1043, H1179B.pdf
Certificate of Analysis 3L-1043, H1179A.pdf
Close pop-up box

Personal Information

* Required Fields

Additional Information

CitationsCook, Cody C., et al. "Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer." Cell death & disease 3.1 (2013): e258.
Facciotti, Marc T., et al. "General transcription factor specified global gene regulation in archaea." Proceedings of the National Academy of Sciences 104.11 (2007): 4630-4635.
Lodge, Jon W., et al. "Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum." Journal of analytical toxicology 32.3 (2008): 248-252.
Kanaani, Jamil, et al. "A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65." The Journal of cell biology 158.7 (2002): 1229-1238.
Laule, Oliver, et al. "Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana." Proceedings of the National Academy of Sciences 100.11 (2003): 6866-6871.
Nyasae, Lydia K., Ann L. Hubbard, and Pamela L. Tuma. "Transcytotic efflux from early endosomes is dependent on cholesterol and glycosphingolipids in polarized hepatic cells." Molecular biology of the cell 14.7 (2003): 2689-2705.
Giguere, Jean-François, and Michel J. Tremblay. "Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1." Journal of virology 78.21 (2004): 12062-12065.
Sethy‐Coraci, Indra, Lara W. Crock, and Samuel C. Silverstein. "PAF‐receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized‐LDL matrices." Journal of leukocyte biology 78.5 (2005): 1166-1174.
Sun, Wei, et al. "Statins activate AMP-activated protein kinase in vitro and in vivo." Circulation 114.24 (2006): 2655-2662.
Schmid, Amy K., et al. "Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon." Nucleic acids research 39.7 (2010): 2519-2533.

Additional Information

No Items Found


Got Questions? We have Answers!

Our team of experts are standing by to help you in every possible way.

Real People, Real Time, Rapid Response

Chip Lindgren


Ken Smith


Kyle Anderson

Procurement & Business Development

Skyler King

Customer Service


Nicole Tran

Customer Service


Casey Kennedy








* Required Fields

*Bulk OEM Multiple Catalog Custom Other
Prod#CAS#*PRODUCT NAMEGrade*Size*QtyTime Frame

Custom magento captcha module from Outsource Online