Lovastatin

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Lovastatin

L-1043
  • CAS: 75330-75-5
  • Formula: C24H36O5
  • MW: 404.55
  • Appearance: White Solid
  • Purity: ≥98 %

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HMG-CoA reductase inhibitor. Lovastatin, Mevinolin, MK-803, inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase). Lovastatin also inhibits MAP kinase and p21ras activation. General transcription factor specified global gene regulation in archaea. Determination of Lovastatin Hydroxy Acid in Female B6C3F1 Mouse Serum. A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Transcytotic Efflux from Early Endosomes Is Dependent on Cholesterol and Glycosphingolipids in Polarized Hepatic Cells. Statin Compounds Reduce Human Immunodeficiency Virus Type 1 Replication by Preventing the Interaction between Virion-Associated Host Intercellular Adhesion Molecule 1 and Its Natural Cell Surface Ligand LFA-1. Statin Inhibition of Fc ReceptorMediated Phagocytosis by Macrophages Is Modulated by Cell Activation and Cholesterol. PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices. Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo. Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon.

Additional Information

SynonymsMevinolin, MK-803, 6-a-Methylcompactin, Monacolin K
Product #L-1043
CAS #75330-75-5
Chemical Name6-a-Methylcompactin
FormulaC24H36O5
MW404.55
AppearanceWhite Solid
Purity≥98 %
SolubilitySoluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Melting Point175.4 °C
Storage Temp-20°C. PROTECT FROM LIGHT AND MOISTURE!
Therapeutic AreaCardiological Disorders, Metabolic Disorders
UseLovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) to reduce risk of cardiovascular disease.

Additional Information

Merck Index13.5608.2001
MDL NumberMFCD00072164
ChemACXX1000555-1
InChIInChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
SMILESCC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Additional Information

GHS Pictograms
RTECSEK7907000
HandlingStore in Tightly Sealed Vial Protect from Light

Additional Information

Certificate of Analysis 1L-1043, H1179C.pdf
Certificate of Analysis 2L-1043, H1179B.pdf
Certificate of Analysis 3L-1043, H1179A.pdf
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