LY294002 EZSolution™

E-2312
  • CAS: 154447-36-6
  • Formula: C19H17NO3
  • MW: 307.34
  • Appearance: Clear colorless solution
  • Purity: ≥98% by HPLC

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LY294002 EZ SOLUTION is a 10 mM (5 mg/1627 µl) solution of PI -3 Kinase inhibitor 

LY-294002 EZ SOLUTION is a cell-permeable, potent and specific phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor that acts on the ATP-binding site of the enzyme (IC50 = 1.4 µM). Also inhibits nonhomologous DNA end-joining (NHED) in the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase.

LY-294002 does not affect the activity of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase, and c-src at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Reported to inhibit histamine secretion in RBL-2H3 cells (IC50 = 5 µM).

 

Additional Information

SynonymsLY-294002 Solution
Product #E-2312
CAS #154447-36-6
Chemical Name2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
FormulaC19H17NO3
MW307.34
AppearanceClear colorless solution
Purity≥98% by HPLC
Storage Temp-20°C

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Certificate of Analysis 1E-2312, J1102A.pdf
Certificate of Analysis 2E-2312, J1102.pdf
Certificate of Analysis 3E-2312, E1277B.pdf
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CitationsLee, Yuree, et al. "Roles of phosphatidylinositol 3-kinase in root hair growth." Plant physiology 147.2 (2008): 624-635.
Kravchenko-Balasha, Nataly, et al. "Shift from apoptotic to necrotic cell death during HPV-induced transformation of keratinocytes." Journal of Biological Chemistry (2009).
Park, Keunhee, et al. "Transcriptional activation of the IL31 gene by NFAT and STAT6." Journal of leukocyte biology 91.2 (2012): 245-257.
McFall, Aidan, et al. "Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase." Molecular and cellular biology 21.16 (2001): 5488-5499.
Pan, Mei-Ren, et al. "Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells." Journal of Biological Chemistry 283.17 (2008): 11155-11163.
Oh, Young Joo, et al. "HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism." The Journal of Immunology 182.9 (2009): 5800-5809.
Blau, Lior, et al. "Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation." Proceedings of the National Academy of Sciences 109.42 (2012): E2875-E2884.
Kim, Yong-Jae, et al. "Nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kB signaling pathways." Infection and immunity (2014): IAI-02007.
Teng, Felicia Yu Hsuan, and Bor Luen Tang. "Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults." Molecular and cellular biochemistry 384.1-2 (2013): 7-19.
Moon, Young-Mee, et al. "IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis." Arthritis research & therapy 14.6 (2012): R246.
Bhattacharya, Poulomi, et al. "Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling." Toxicology and applied pharmacology 258.1 (2012): 118-123.
Bhattacharya, Poulomi, et al. "Glutathione S-transferase class mu regulation of apoptosis signal-regulating kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries." Toxicology and applied pharmacology 267.1 (2013): 49-56.
Kitahara, Atsuko, et al. "The novel mechanisms concerning the inhibitions of palmitate-induced proinflammatory factor releases and endogenous cellular stress with astaxanthin on MIN6 β-cells." Marine drugs 15.6 (2017): 185.

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