Axura; Ebix; Namenda; NSC 102290; SUN Y7017
41100-52-1
215.8
C12H21N • HCl
DMF, DMSO, Ethanol, PBS (pH 7.2)
Room Temperature
Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist, that stimulates dopamine release. Memantine hydrochloride (1-amino3, 5-dimethyladamantane hydrochloride) is a tricyclic amine chemically and pharmacologically related to the anti-viral prototype amantadine and its α-methyl derivative rimantadine.
Memantine is used in Parkinson’s disease and movement disorders. Memantine hydrochloride is currently known as the latest treatment for moderate-to-severe Alzheimer disease (AD). The drug acts by noncompetitively binding to the N-methyl d-aspartate (NMDA) receptors of neurons in brain tissue to prevent overstimulation by glutamate. When this excitatory neurotransmitter over activates NMDA receptors in a tonic manner, an excessive influx of neurotoxic calcium ions follows. The resultant excitotoxicity may play a role in the impairment of memory and cognition in AD.
Because memantine has a low-to-moderate affinity for NMDA receptors, it does not seem to block normal glutamate transmission; rather, it reduces abnormal neurotransmitter-mediated activation of the receptors, thereby potentially reducing excitotoxic neuronal damage. This form of neuroprotection may explain the improved cognition in patients with AD.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
