MG-132

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MG-132

M-1157
  • CAS: 133407-82-6
  • Formula: C26H41N3O5
  • MW: 475.6
  • Appearance: White Powder
  • Purity: >98%

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MG-132 is a cell permeable reversible proteosome inhibitor. MG-132 is also called as carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, is a peptide aldehyde, part of a group of chemicals capable of inhibiting proteases, such as serine proteases and calpain etc. MG-132 reduces the degradation of IκB (inhibitory κB), GRK2 (G-protein-receptor kinase 2), ARC (apoptosis repressor with caspase recruitment domain), and HSP (heat shock proteins), all of which exert beneficial effects on acute myocardial ischemia. Moderate proteasome inhibition by MG132 results in the upregulation of anti-oxidative enzymes, and it protects rat myocytes against H2O2-mediated oxidative stress. It also inhibits 5-lipoxygenase that selectively disrupts function of c-Myc in cancer cells and NF- κB activation.

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SynonymsZ-LLL-CHO, Z-Leu-Leu-Leu-CHO
Product #M-1157
CAS #133407-82-6
Chemical NameZ-Leu-Leu-Leu-aldehyde; Z-LLL-CHO
FormulaC26H41N3O5
MW475.6
AppearanceWhite Powder
Purity>98%
Solubility45 mg/ml in DMSO, 45 mg/ml in DMF, 45 mg/ml in Ethanol.
Storage TempStore desiccated at -20°C
UseUsed in Proteosome activity assay.

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msds 1M-1157, MG-132, SDS, diamond format.pdf
Certificate of Analysis 1M-1157, J1223A.pdf
Certificate of Analysis 2M-1157, J1223.pdf
Certificate of Analysis 3M-1157, H1285D.pdf
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CitationsMOLECULAR BIOLOGY, PATHOBIOLOGY, AND GENETICS:\n Src-Induced Cisplatin Resistance Mediated by Cell-to-Cell Communication\n Elizabeth Peterson-Roth, Cathleen M. Brdlik, and Peter M. Glazer\n Cancer Res., Apr 2009; 69: 3619 - 3624.
REGULAR PAPERS:\n Functional Characterization of Phytochrome Autophosphorylation in Plant Light Signaling\n Yun-Jeong Han, Hwan-Sik Kim, Yong-Min Kim, Ah-Young Shin, Si-Seok Lee, Seong Hee Bhoo, Pill-Soon Song, and Jeong-Il Kim\n Plant Cell Physiol., Apr 2010; 51: 596 - 609.
SYSTEMS AND SYNTHETIC BIOLOGY:\n The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses\n Jong Hum Kim and Woo Taek Kim\n Plant Physiology, Jul 2013; 162: 1733 - 1749.
RSF1 Is a Positive Regulator of NF-kB-Induced Gene Expression Required for Ovarian Cancer Chemoresistance
Oncogenic function of p34SEI-1 via NEDD4 1 mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes
In COS Cells Vpu Can Both Stabilize Tetherin Expression and Counteract Its Antiviral Activity
Identification of repurposed small molecule drugs for chordoma therapy
USP35 regulates mitotic progression by modulating the stability of Aurora B
VBP1 represses cancer metastasis by enhancing HIF-1 alpha degradation induced by pVHL
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death
Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon
Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment
Studies on the Epigenetic and Transcriptional Regulation of LSD1 in Inflammatory Response
ReferenceSIGNAL TRANSDUCTION: Small Ubiquitin-like Modifier (SUMO) Modification of Zinc Finger Protein 131 Potentiates Its Negative Effect on Estrogen Signaling, Yohan Oh and Kwang Chul Chung, J. Biol. Chem., May 2012; 287: 17517 - 17529.
LYMPHOID NEOPLASIA: The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax, Kimberly A. Fryrear, Blood, Feb 2012; 119: 1173 - 1181.
COMP-Ang1 stimulates HIF-1alpha mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment
UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131., Yohan Oh and Kwang Chul Chung, J. Biol. Chem. 2013 288: 9102-9111.
SYSTEMS AND SYNTHETIC BIOLOGY: The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses. Jong Hum Kim and Woo Taek Kim. Plant Physiology. Jul 2013. 162: 1733-1749.
HOST RESPONSE AND INFLAMMATION: Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa Induce Interleukin 1 Expression via the Akt/NF-kB Signaling Pathways. Kim, Y. J. et al. Infect Immun.Aug 2014. 82: 3252-3260.
ENZYME CATALYSIS AND REGULATION:\n Binding of MG132 or Deletion of the Thr Active Sites in HslV Subunits Increases the Affinity of HslV Protease for HslU ATPase and Makes This Interaction Nucleotide-independent\n Eunyong Park, Jung Wook Lee, Soo Hyun Eom, Jae Hong Seol, and Chin Ha Chung\n J. Biol. Chem., Nov 2008; 283: 33258 - 33266.
STRUCTURE AND ASSEMBLY:\n Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion\n Pablo Gastaminza, Guofeng Cheng, Stefan Wieland, Jin Zhong, Wei Liao, and Francis V. Chisari\n J. Virol., Mar 2008; 82: 2120 - 2129.
Involvement of Protein Synthesis and Degradation in LongTerm Potentiation of Schaffer Collateral CA1 Synapses
CELL BIOLOGY:\n UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131\n Yohan Oh and Kwang Chul Chung\n J. Biol. Chem., Mar 2013; 288: 9102 - 9111.

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