Mithramycin A, Streptomyces plicatus, MA

M-1072
  • CAS: 18378-89-7
  • Formula: C52H76O24
  • MW: 1085.2
  • Appearance: Yellow Solid
  • Purity: 95%

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Antibiotic which also serves as a DNA binding fluorescent dye. Inhibits RNA synthesis.Mithramycin A Sensitizes TRAIL-Mediated Apoptosis in Various Malignant Cancer Cells.Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation ofXIAP gene promoter through Sp1 sites.Both subcutaneous and intraperitoneal MIT significantly suppressed the growth of carcinoid cells in nude mouse models.Mithramycin encapsulated in polymeric micelles by microfluidic technology a novel therapeutic protocol for beta-thalassemia.

Additional Information

SynonymsPlicamycin, Aurelic Acid,
Product #M-1072
CAS #18378-89-7
Chemical Name(2S,3S)-2-[(2S,4R,5R,6R)-4-[(2S,4R,5R,6R)-4-[(2S,4S,5R,6R)-4,5-DIHYDROXY-4,6-DIMETHYLOXAN-2-YL]OXY-5-HYDROXY-6-METHYLOXAN-2-YL]OXY-5-HYDROXY-6-METHYLOXAN-2-YL]OXY-3-[(1S,3S,4R)-3,4-DIHYDROXY-1-METHOXY-2-OXOPENTYL]-6-[(2S,4R,5S,6R)-4-[(2S,4R,5S,6R)-4,5-DIH
FormulaC52H76O24
MW1085.2
AppearanceYellow Solid
Purity95%
SolubilityCoelenterazine and the derivatives can be reconstituted by dissolving in methanol or ethanol. Do not dissolve in dimethyl-sulfoxide (DMSO); have extremely low solubility in water.
Melting Point180-183°C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseMithramycin A is an antineoplastic antibiotic used in the treatment of testicular cancer,Paget's disease of bone, chronic myeloid leukemia

Additional Information

Merck IndexMerck Index: 12.7696.1996
MDL NumberMFCD00135618
ChemACXX1009161-5
InChIInChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27?,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43+,44-,45-,49+,50+,51-,52+/m1/s1
SMILESCc1c(cc2cc3c(c(c2c1O)O)C(=O)[C@H](C(C3)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]4C[C@H]([C@@H]([C@H](O4)C)O)O[C@H]5C[C@H]([C@@H]([C@H](O5)C)O)O[C@H]6C[C@]([C@@H]([C@H](O6)C)O)(C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@H]([C@@H]([C@H](O8)C)O)O

Additional Information

RTECSPZ2800000
HandlingWarning.Toxic. May be Carcinogenic. May be Teratogenic. Protect from Light Protect from Moisture. Hygroscopic.

Additional Information

Certificate of Analysis 1M-1072, F1242C.pdf
Certificate of Analysis 2M-1072, F1242B.pdf
Certificate of Analysis 3M-1072, F1242A.pdf
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