Mitomycin C,Stem cells reagent hESCs

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Mitomycin C,Stem cells reagent hESCs

M-1108
  • CAS: 50-07-7
  • Formula: C15H18N4O5
  • MW: 334.3
  • Appearance: Blue-Violet Solid.
  • Purity: >99%

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Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems. 

This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.

Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria. Mitomycin c role in pluripotent stem cells research expands into the CRISPR/Cas9 revolution to permit efficient gene correction.

 

Additional Information

SynonymsMMC, Mutamycin, Ametycin, Mitocin-C
Product #M-1108
CAS #50-07-7
Chemical Name[(1AS,8S,8AR,8BS)-6-AMINO-8A-METHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2',3':3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYL CARBAMATE
FormulaC15H18N4O5
MW334.3
AppearanceBlue-Violet Solid.
Purity>99%
SolubilityClear blue-violet solution at 10mg/ml in DMSO or CH3OH.
Storage TempStore desiccated at -20°C.
Therapeutic AreaOncological Disorders
UseA DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells use in cancer

Additional Information

Merck Index13.6236[p.2001
MDL NumberMFCD00078109
ChemACXX1004059-0
InChIInChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
SMILESCC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

Additional Information

GHS Pictograms
RTECSCN0700000
UN #'SUN 2811
PACKING GROUPII
HandlingStore in Tightly Sealed Vial Warning.Toxic. Protect from Light

Additional Information

msds 1M-1108, Mitomycin C, SDS, diamond format.pdf
Certificate of Analysis 1M-1108, H1358A.pdf
Certificate of Analysis 2M-1108, H1184D.pdf
Certificate of Analysis 3M-1108, H1184C.pdf
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