Myriocin | CAS [35891-70-4] | Potent immunosuppressant | A.G. Scientific

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Myriocin, Mycelia sterilia

M-1235
  • CAS: 35891-70-4
  • Formula: C21H39NO6
  • MW: 401.54
  • Appearance: White to grey Powder
  • Purity: 97% by TLC

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Potent immunosuppressant; reported to be 10 to 100-fold more potent than cyclosporin (C1199). Fungal antibiotic. Apoptosis inducer,depletes cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC=15nM).

Additional Information

SynonymsThermozymocidin, ISP-I
Product #M-1235
CAS #35891-70-4
Chemical Name(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
FormulaC21H39NO6
MW401.54
AppearanceWhite to grey Powder
Purity97% by TLC
SolubilitySoluble in DMSO 25mg/ml (briefly heat in boiling water bath). Also may dilute in base (5mg/ml, 50mM NaOH).
Storage Temp-20°C
UseMyriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi

Additional Information

MDL NumberMFCD01632772
ChemACXX1223136-8
InChIInChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
SMILESCCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O

Additional Information

GHS Pictograms
RTECSJX3890000
UN #'SUN 2811
PACKING GROUPIII
HandlingStore solutions at -20C

Additional Information

Certificate of Analysis 1M-1235_M-1235,_C1129.pdf
Certificate of Analysis 2M-1235_M-1235,_C1125.pdf
Certificate of Analysis 3M-1235_M-1235,_B1614.pdf
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