Nogalamycin

N-2607
  • CAS: 1404-15-5
  • Formula: C39H49NO16
  • MW: 787.8
  • Appearance: Red orange solid
  • Purity: >95% by HPLC

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Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent anthracycline antibiotic and antitumor agent that interacts with DNA by intercalation, binding with d(CGTACG), d(ATGCAT).

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Additional Information

SynonymsU 15167, Antibiotic U 15167
Product #N-2607
CAS #1404-15-5
FormulaC39H49NO16
MW787.8
AppearanceRed orange solid
Purity>95% by HPLC
Storage Temp4°C
Therapeutic AreaInfectious Diseases
UseNogalamycin is a potent antibacterial and antitumor agent that interacts with DNA by intercalation

Additional Information

MDL NumberMFCD00083442
PubChecm ID4526
InChIInChI=1S/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3/t14-,19-,24-,25-,29-,31+,32-,33-,35+,36-,37-,38+,39+/m0/s1
SMILESC[C@H]1[C@@H]([C@@]([C@H]([C@@H](O1)O[C@H]2C[C@]([C@@H](c3c2c(c4c(c3)C(=O)c5c(c(cc6c5O[C@H]7[C@H]([C@@H]([C@H]([C@@]6(O7)C)O)N(C)C)O)O)C4=O)O)C(=O)OC)(C)O)OC)(C)OC)OC

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