Paclitaxel (Taxol), Taxus brevifolia

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Paclitaxel (Taxol), Taxus brevifolia

P-1027
  • CAS: 33069-62-4
  • Formula: C47H51NO14
  • MW: 853.9
  • Appearance: White Crystalline Powder
  • Purity: 98%

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Anti-tumor agent isolated from the bark of the yew tree.Attached is a published reference from researchers who have used our paclitaxel product.Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFB pathway.Weekly paclitaxel has limited activity in esophageal cancer. The median survival, modest activity, and tolerance of therapy indicate that weekly paclitaxel may be an option in patients unable to tolerate combination chemotherapy. .Paclitaxel Enhances TF Protein Expression and Surface Activity.Paclitaxel Enhances Thrombin-Induced Endothelial Tissue Factor Expression via c-Jun Terminal NH.

Additional Information

SynonymsTaxol, Baccatin III N-benzyl-phenylisoserine ester
Product #P-1027
CAS #33069-62-4
Chemical NameBaccatin III N-benzyl-β-phenylisoserine ester
FormulaC47H51NO14
MW853.9
AppearanceWhite Crystalline Powder
Purity98%
SolubilityDMSO
Storage Temp-20°C. PROTECT FROM LIGHT! WARNING: TOXIC! IRRITANT!
Therapeutic AreaOncological Disorders
UseAn antineoplastic and apoptosis inducing agent

Additional Information

Merck Index12.7117.1996
MDL NumberMFCD00869953
ChemACXX1009807-6
InChIInChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
SMILESCC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](c5ccccc5)NC(=O)c6ccccc6)O)O)OC(=O)c7ccccc7)(CO4)OC(=O)C)O)C)OC(=O)C

Additional Information

RTECSDA8340700
HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.

Additional Information

Certificate of Analysis 1P-1027, J1297.pdf
Certificate of Analysis 2P-1027, F1252B.pdf
Certificate of Analysis 3P-1027, F1252A.pdf
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