PD 98059 EZSolution

E-2314
  • CAS: 167869-21-8
  • Formula: C16H13NO3
  • MW: 267.28
  • Appearance: Liquid
  • Purity: 98% by HPLC

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A 10 mM (5 mg in 1870 l) solution of PD98059 (Cat. No. 1666-5) in anhydrous DMSO.

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SynonymsMEK Inhibitor, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Product #E-2314
CAS #167869-21-8
Chemical Name2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
FormulaC16H13NO3
MW267.28
AppearanceLiquid
Purity98% by HPLC
Melting Point164-165 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UsePotent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK) use in cancer

Additional Information

MDL NumberMFCD00671789
ChemACXX1038243-7
InChIInChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
SMILESCOc1cccc(c1N)c2cc(=O)c3ccccc3o2

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HandlingProtect from air and light

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CitationsMeade, Aidan D., et al. "Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes." Faraday discussions 187 (2016): 213-234.
Kim, Mi-Kyoung, et al. "Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible factor-a (HIF-1a) upregulation." Archives of oral biology 59.2 (2014): 102-110.
Kim, Dongbum, Younghee Lee, and Hyung-Joo Kwon. "Expression of IFN-y induced by CpG-DNA stimulation in a human myeloid leukemia cell line KG-1." Journal of the Korean Society for Applied Biological Chemistry 56.5 (2013): 553-558.
Meade, Aidan D., et al. "Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes." Faraday discussions 187 (2016): 213-234.\n
Kim, Hak-Jae, et al. "15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes." Molecular medicine reports 12.3 (2015): 4141-4148.
Bar-Lev, Tali H., et al. "Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes." Molecular and cellular endocrinology 415 (2015): 12-23.\n
Lee, Hae-Ri, et al. "The poly-y-d-glutamic acid capsule surrogate of the Bacillus anthracis capsule induces nitric oxide production via the platelet activating factor receptor signaling pathway." Molecular immunology 68.2 (2015): 244-252.
Park, Keunhee, et al. "Transcriptional activation of the IL31 gene by NFAT and STAT6." Journal of leukocyte biology 91.2 (2012): 245-257.

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