Phorbol-12-myristate-13-acetate

P-1039
  • CAS: 16561-29-8
  • Formula: C36H56O8
  • MW: 616.8
  • Appearance: White to off-white solid.
  • Purity: ≥99%

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Potent mouse skin tumor promoter. Also activates Protein Kinase C. Frequent and Strong Antibody-Mediated Natural Killer Cell Activation in Response to HIV-1 Env in Individuals with Chronic HIV-1 Infection. HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function. Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes. A T-bet-Independent Role for IFN-/ in Regulating IL-2 Secretion in Human CD4+ Central Memory T Cells. Blockade of Virus Infection by Human CD4+ T Cells via a Cytokine Relay Network.

Additional Information

SynonymsPMA; PKC activator;TPA; 12-O-Tetradecanoyl-phorbol13-acetate; Phorbol myristate acetate
Product #P-1039
CAS #16561-29-8
Chemical Name(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
FormulaC36H56O8
MW616.8
AppearanceWhite to off-white solid.
Purity≥99%
SolubilitySoluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
Melting Point50-70 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseIt is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia

Additional Information

Merck IndexMerck Index: 13.7417.2001
MDL NumberMFCD00036736
ChemACXX1009782-4
InChIInChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1
SMILESCCCCCCCCCCCCCC(=O)O[C@@H]2C(C)[C@]1(O)C4/C=C(/C)C(=O)[C@@]4(O)CC(CO)=C/[C@H]1[C@H]3[C@]2(OC(C)=O)C3(C)C

Additional Information

GHS Pictograms
RTECSQH4377000
HandlingWarning.Toxic. Store in Tightly Sealed Vial

Additional Information

Certificate of Analysis 1P-1039, J1119A.pdf
Certificate of Analysis 2P-1039, J1119.pdf
Certificate of Analysis 3P-1039, H1427.pdf
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