PMSF

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PMSF

P-2401
  • CAS: 329-98-6
  • Formula: C7H7FO2S
  • MW: 174.2
  • Appearance: White Crystalline Solid
  • Purity: 98%

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An irreversible inhibitor of serine proteases (such as thrombin, trypsin and chymotrypsin) and mammalian acetylcholinesterase. It causes sulfonylation of the active-site serine residues. Inhibits cysteine proteases like papain (reversible by DTT treatment). Also inhibits internucleosomal DNA fragmentation in immature thymocytes.

PMSF is inactivated in aqueous solutions. The rate of inactivation increases with increasing pH and is faster at 25°C than at 4°C. The half-life of a 20mM aqueous solution of PMSF is ~35 minutes at pH 8.0. This short half-life means that aqueous solutions of PMSF can be safely discarded after they have been rendered alkaline (pH >8.6) and stored for several hours at room temperature. Working Concentration: 0.1-1.0mM.

 

Additional Information

SynonymsToluenesulfonyl fluoride, Benzylsulfonyl fluoride, Phenylmethylsulfonyl fluoride
Product #P-2401
CAS #329-98-6
Chemical Nameα-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, Phenylmethylsulfonyl fluoride
FormulaC7H7FO2S
MW174.2
AppearanceWhite Crystalline Solid
Purity98%
SolubilitySoluble in 10% pure ethanol, chloroform and diethyl ether. Clear, colorless solution in chloroform and diethyl ether.
Melting Point93.8°C
PreparationDissolve PMSF in isopropanol at 1.74 mg/mL (10 mM); store in aliquots at -20°C.
Storage TempStore desiccated at +4°C. Protect from moisture.
UsePMSF is a serine protease inhibitor commonly used in the preparation of cell lysates

Additional Information

MDL NumberMFCD00007424
ChemACXX1032413-5
InChIInChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
SMILESc1ccc(cc1)CS(=O)(=O)F

PMSF has limited water solubility, it must be dissolved in a small amount of solvent, such as ethanol.

Additional Information

GHS Pictograms
RTECSXT8040000
UN #'SUN 2928
PACKING GROUPII
HandlingProtect from moisture and light. Wear gloves, Corrosive.
Hazard ImageYes

Additional Information

msds 1P-2401, PMSF, SDS, diamond format.pdf
Certificate of Analysis 1P-2401, H1328C.pdf
Certificate of Analysis 2P-2401, H1328B.pdf
Certificate of Analysis 3P-2401, H1328A.pdf
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