PP2 | CAS#172889-27-9 |  Selective Src tyrosine kinase inhibitor |Src cellular signaling, PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinasesPP2 is a substance used in cancer research as a selective inhibitor for Src

More Views

PP2

P-1103
  • CAS: 172889-27-9
  • Formula: C15H16ClN5
  • MW: 301.8
  • Appearance: Off White Solid
  • Purity: 98%

Hazardous
Add to Cart Bulk Inquiry
PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases with 10,000-fold selectivity over ZAP-70 and JAK2.PP2 strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100M) and JAK2 (50M).A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LT2 Gonadotrope Cells.VASCULAR BIOLOGY Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity .PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant.Binding of IgG-Opsonized Particles to FcR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation.

Additional Information

Synonyms4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4,d]pyrimidine
Product #P-1103
CAS #172889-27-9
Chemical Name1-tert-Butyl-3-(4-chlorophenyl)- 1H-pyrazolo[3,4-d]pyrimidin-4-amine
FormulaC15H16ClN5
MW301.8
AppearanceOff White Solid
Purity98%
SolubilitySoluble in water, methanol, DMSO, DMF with moderate ethanol solubility
Melting Point214-216 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UsePP 2 is an effective and selective inhibitor of c-Src family kinases use in cervical cancer

Additional Information

MDL NumberMFCD01568210
ChemACXX1486321-1
InChIInChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
SMILESCC(C)(C)n1c2c(c(n1)c3ccc(cc3)Cl)c(ncn2)N

Additional Information

GHS Pictograms
HandlingStore in Tightly Sealed Vial

Additional Information

Certificate of Analysis 1P-1103_P-1103,_D1189.pdf
Certificate of Analysis 2P-1103_P-1103,_C1151.pdf
Close pop-up box

Personal Information

* Required Fields

Additional Information

No Items Found

Newsletter

Got Questions? We have Answers!

Our team of experts are standing by to help you in every possible way.

Real People, Real Time, Rapid Response

Chip Lindgren

Founder/CEO

Ken Smith

Operations

Kyle Anderson

Procurement & Business Development

Skyler King

Customer Service

 

Nicole Tran

Customer Service

 

Casey Kennedy

Marketing

 

 

 

 

 

BULK ENQUIRY FORM

* Required Fields

*
*
*
*
*
*Bulk OEM Multiple Catalog Custom Other
Prod#CAS#*PRODUCT NAMEGrade*Size*QtyTime Frame

Custom magento captcha module from Outsource Online