Puromycin, dihydrochloride


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Puromycin, dihydrochloride P-1033
Promotion ends on Jan 31st. Use Code: AG25
  • CAS: 58-58-2
  • Formula: C22H29N7O5 2HCl
  • MW: 544.4
  • Appearance: White to off-white powder
  • Purity: ≥98% by HPLC





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Puromycin Dihydrochloride is the hydrochloride salt form of puromycin, an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties. Puromycin's main application is in cell biology as a selective antibiotic agent in cell culture systems for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase (PAC). Puromycin’s longstanding application as a gene selection antibiotic has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system.

Recently researchers have developed a prodrug strategy for selective cancer therapy using a masked cytotoxic agent Fmoc-Lys(Ac)-Puromycin, which can be sequentially activated by histone deacetylases (HDACs) and cathepsin L (CTSL) to kill cancer cells expressing high levels of both enzymes. The data gathered indicates that Fmoc-Lys(Ac)-Puromycin can substantially improve anti cancer efficacy and can be developed into potential selective cancer therapy.


Additional Information

SynonymsStylomycin dihydrochloride, CL 13900 dihydrochloride, CL16536, NSC 3055, P638 dihydrochloride.
Product #P-1033
CAS #58-58-2
Chemical Name(S) 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine,3'-(a-Amino-p-methoxy-hydocinnamamido)-3'-dexoy-N,N-dimethyladenosine.2HCl
FormulaC22H29N7O5 2HCl
AppearanceWhite to off-white powder
Purity≥98% by HPLC
SolubilitySoluble in water (50 mg/ml), ethanol (~1 mg/ml), DMSO (~13 mg/ml), DMF (~14 mg/ml), and PBS, pH 72 (~10 mg/ml)
Melting Point175-177 °C
Boiling Point752.16 °C
Storage Temp-20°C
Therapeutic AreaInfectious Diseases
UseAn aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene

Additional Information

Merck Index14: 7943
MDL NumberMFCD00866328

Additional Information

UN #'SUN 2811

Additional Information

msds 1P-1033, SDS.pdf
Certificate of Analysis 1P-1033, J1006.pdf
Certificate of Analysis 2P-1033, H1401B.pdf
Certificate of Analysis 3P-1033, H1401A.pdf

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