Puromycin Dihydrochloride Solution

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Puromycin Dihydrochloride Solution

P-1033-SOL
  • CAS: 58-58-2
  • Formula: C22H29N7O5.2HCl
  • MW: 544.43
  • Appearance: Clear and colorless to light yellow solution
  • Purity: ≥99%

Hazardous
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AG Scientific's Puromycin dihydrochloride solution is a sterile filterate solution.

Puromycin is an aminonucleoside antibiotic that causes early chain termination within the ribosome during translation. This inhibition of translation is effective in both in vivo and in vitro applications, making it an ideal tool for protein synthesis studies. While selection for E. Coli cells is possible with puromycin, it is more commonly and effectively used for mammalian cell selection.

It is active against gram-positive microorganisms, less active against acid-fast bacilli and more weakly active against gram-negative microorganisms. The growth of bacteria, protozoa, algae and mammalian cells is quickly halted by puromycin. However, cells with the pac gene have resistance, its gene product is puromycin-N-acetyl-transferase which inactivates puromycin through acetylation. Research has shown puromycin to be effective against certain tumors.

Recently researchers have developed a prodrug strategy for selective cancer therapy using a masked cytotoxic agent Fmoc-Lys(Ac)-Puromycin, which can be sequentially activated by histone deacetylases (HDACs) and cathepsin L (CTSL) to kill cancer cells expressing high levels of both enzymes. The data gathered indicates that Fmoc-Lys(Ac)-Puromycin can substantially improve anti cancer efficacy and can be developed into potential selective cancer therapy.

APPLICATIONS

Puromycin is soluble in water and is often used as a selective agent in molecular biology research.

Puromycin has a longstanding application as a gene selection antibiotic and a powerful new role in Genome editing utilizing the CRISPR/Cas9 system.

Purity data is for a concentration of 10 mg/ml.

 

Additional Information

SynonymsStylomycin, P638
Product #P-1033-SOL
CAS #58-58-2
Chemical Name(S) 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine,3'-(a-Amino-p-methoxy-hydocinnamamido)-3'-dexoy-N,N-dimethyladenosine.2HCl
FormulaC22H29N7O5.2HCl
MW544.43
AppearanceClear and colorless to light yellow solution
Purity≥99%
SolubilitySoluble in DMSO (1M).
Storage Temp-20°C
UsePuromycin dihydrochloride is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium

Additional Information

Merck Index13.8044.2001
MDL NumberMFCD00012691
ChemACXX1017033-1
InChIInChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1
SMILESCN(C)c1c2c(ncn1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](Cc4ccc(cc4)OC)N)O.Cl.Cl

Additional Information

HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Moisture.

Additional Information

Certificate of Analysis 1P-1033-SOL, H1401A.pdf
Certificate of Analysis 2P-1033-SOL, H1401.pdf
Certificate of Analysis 3P-1033-SOL, H1384.pdf
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