(R,S)-Rolipram, Inhibitor of PDE IV

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(R,S)-Rolipram, Inhibitor of PDE IV

R-1012
  • CAS: 61413-54-5
  • Formula: C16H21N03
  • MW: 275.4
  • Appearance: White Solid
  • Purity: > 99%

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Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.

Additional Information

SynonymsZK-62711
Product #R-1012
CAS #61413-54-5
Chemical Name(R,S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
FormulaC16H21N03
MW275.4
AppearanceWhite Solid
Purity> 99%
SolubilitySoluble in Water
Melting Point132°C
Storage TempStore at +4°C under desiccating conditions.
UseUsed in Neurodegenrative Disease research as a PDE4 inhibitor.

Additional Information

Merck Index13.8332.2001
MDL NumberMFCD00270906
ChemACXX1038250-2
InChIInChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILESCOc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

Additional Information

RTECSUY5749237
HandlingStore in Tightly Sealed Vial

Additional Information

msds 1R-1012, Rolipram, SDS, diamond format.pdf
Certificate of Analysis 1R-1012, F1254E.pdf
Certificate of Analysis 2R-1012, F1254D.pdf
Certificate of Analysis 3R-1012, F1254C.pdf
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