Salinomycin chemical structure | CAS 53003-10-4 | Polyether Ionophore | AG Scientific, Inc.

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Salinomycin

S-2747
  • CAS: 53003-10-4
  • Formula: C42H70O11
  • MW: 751.0 Da
  • Appearance: Lyophilized light-yellow powder
  • Purity: 99%

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*Please inquire the availability for this product. Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

 

Source: Streptomyces sp.

Additional Information

SynonymsAntibiotic 61477, Coxistac, Bio-Cox, Salocin
Product #S-2747
CAS #53003-10-4
Chemical Name(2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butan
FormulaC42H70O11
MW751.0 Da
AppearanceLyophilized light-yellow powder
Purity99%
SolubilityDMSO: clear colorless solution at 10 mg/mL
Storage Temp-20°C
Therapeutic AreaInfectious diseases
UseSalinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity

Additional Information

MDL NumberMFCD00865281
InChIInChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
SMILESCC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O

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HandlingDanger! Fatal if swallowed.

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