Sorafenib (base)

S-2727
  • CAS: 284461-73-0
  • Formula: C21 H16 Cl F3 N4 O3
  • MW: 464.829

Hazardous
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 Raf-1 inhibitor (and other kinases)

Additional Information

Product #S-2727
CAS #284461-73-0
FormulaC21 H16 Cl F3 N4 O3
MW464.829
SolubilitySoluble in DMSO (~20 mg/ml), Hot Methanol, DMF (~20 mg/ml), 1:2 solution of DMSO:PBS(PH 7.2 ) (~0.3 mg/ml), 100% ethanol, and ethyl acetate.
Melting Point202.2-203.9 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseSorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation use in cancer

Additional Information

MDL NumberMFCD06411450
ChemACXX1511955-8
InChIInChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
SMILESCNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl

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