Staurosporine, Cell permeable inhibitor of protein kinases

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Staurosporine, Cell permeable inhibitor of protein kinases

S-1016
  • CAS: 62996-74-1
  • Formula: C28H26N4O3
  • MW: 466.5
  • Appearance: Pale Yellow Solid
  • Purity: 98%

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A cell permeable general inhibitor of protein kinases. Inhibits CaM kinase ), myosin lightchain kinase , protein kinase A, protein kinase and protein kinase g .Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells.

Additional Information

SynonymsStaurosporine, Antibiotic AM-2282
Product #S-1016
CAS #62996-74-1
Chemical Name(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14(5H)-ONE
FormulaC28H26N4O3
MW466.5
AppearancePale Yellow Solid
Purity98%
SolubilityWater (10 mg/ml)
Storage Temp+4°C
Therapeutic AreaOncological Disorders
UsePotent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells

Additional Information

MDL NumberMFCD18252446
ChemACXX1000602-5
InChIInChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
SMILESC[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC

Additional Information

HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light

Additional Information

Certificate of Analysis 1S-1016, E1076.pdf
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