Thapsigargin, ER stress inducer

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Thapsigargin, ER stress inducer

T-1014
  • CAS: 67526-95-8
  • Formula: C34H50O12
  • MW: 650.8
  • Appearance: White to off-white lyophilized powder
  • Purity: ≥95%

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Thapsigargin is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Thapsigargin increases cytosolic calcium levels through release from intracellular calcium stores. Depletion of ER calcium stores leads to Ca2+ influx via activation of store (voltage)-operated calcium channels in the plasma membrane, mediating numerous physiological functions, including exocytosischemotaxis, transcription, cell division, and apoptosisThere are preclinical indications that the drug may have anticancer potential.

According to a recent paper Thapsigargin indirectly and robustly inhibits nonsense-mediated RNA decay (NMD), and this potential of thapsigargin has been harnessed to develop a method that detects NMD efficiency inside the cell.

 

Additional Information

Synonymsthaps, tg
Product #T-1014
CAS #67526-95-8
Chemical Name[(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL] OCTANOATE
FormulaC34H50O12
MW650.8
AppearanceWhite to off-white lyophilized powder
Purity≥95%
SolubilityClear and colorless solution at 10 mg/mL of CH3CN
Storage Temp-20°C, Protect from light & oxygen! WARNING: HARMFUL! HIGHLY IRRITANT! MAY BE CARCINOGENIC!
Therapeutic AreaOncological Disorders
UseIt is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase

Additional Information

Merck IndexMerck Index: 13.9342
MDL NumberMFCD00083511
ChemACXX1096797-0
InChIInChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
SMILESCCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

Additional Information

UN #'SUN 2811
PACKING GROUPII
HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light

Additional Information

msds 1T-1014, Thapsigargin,SDS, diamond format.pdf
Certificate of Analysis 1T-1014, H1380D.pdf
Certificate of Analysis 2T-1014, H1380C.pdf
Certificate of Analysis 3T-1014, H1380B.pdf
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