Trichostatin A CAS 58880-19-6 Inhibits HDAC families of enzymes, anticancer application

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Trichostatin A, TSA

T-1052
  • CAS: 58880-19-6
  • Formula: C17H22N2O3
  • MW: 302.4
  • Appearance: Beige powder
  • Purity: >99%

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Trichostatin A (TSA), is an antifungal antibiotic. It’s cytostatic and differentiating properties are utilized in mammalian cell culture. It is a potent and specific, nonselective HDAC inhibitor, shown to have anti-inflammatory and neuroprotective properties. It inhibits all class I and class II HDAC’s and induces histone acetylation. TSA interacts reversibly with the HDAC catalytic site preventing binding of the substrate. HDACs - Classes I, II, and IV all require a zinc molecule as an essential cofactor in their active site and are inhibited by Zn2+-binding HDAC inhibitor - Trichostatin A (TSA). 

Studies have shown antiproliferative and HDAC inhibitory activity of TSA in vitro, in human breast cancer cell lines. its antitumor efficacy and toxicity has been studied in vivo in a carcinogen-induced rat mammary cancer model, which provided evidence for potent dose-dependent antitumor activity of TSA against breast cancer in vitro and in vivo. These studies strongly support HDAC as a molecular target for anticancer therapy in breast cancer.

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    Additional Information

    SynonymsTSA
    Product #T-1052
    CAS #58880-19-6
    FormulaC17H22N2O3
    MW302.4
    AppearanceBeige powder
    Purity>99%
    SolubilityMay be dissolved in DMSO (15mg/ml); or Ethanol (3mg/ml).
    Melting Point150-151°C
    Storage Temp-20°C, Solutions stored at -20°C are good for 1- 2 months. Store in Tightly Sealed Vial.

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    Additional Information

    RTECSMI5215000

    Additional Information

    Certificate of Analysis 1T-1052, J1211.pdf
    Certificate of Analysis 2T-1052, J1134.pdf
    Certificate of Analysis 3T-1052, G1001.pdf
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