Trichostatin A (TSA), is an antifungal antibiotic. It’s cytostatic and differentiating properties are utilized in mammalian cell culture. It is a potent and specific, nonselective HDAC inhibitor, shown to have anti-inflammatory and neuroprotective properties. It inhibits all class I and class II HDAC’s and induces histone acetylation. TSA interacts reversibly with the HDAC catalytic site preventing binding of the substrate. HDACs - Classes I, II, and IV all require a zinc molecule as an essential cofactor in their active site and are inhibited by Zn2+-binding HDAC inhibitor - Trichostatin A (TSA).
Studies have shown antiproliferative and HDAC inhibitory activity of TSA in vitro, in human breast cancer cell lines. its antitumor efficacy and toxicity has been studied in vivo in a carcinogen-induced rat mammary cancer model, which provided evidence for potent dose-dependent antitumor activity of TSA against breast cancer in vitro and in vivo. These studies strongly support HDAC as a molecular target for anticancer therapy in breast cancer.
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Additional Information
| Synonyms | TSA |
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| Product # | T-1052 |
| CAS # | 58880-19-6 |
| Formula | C17H22N2O3 |
| MW | 302.4 |
| Appearance | Beige powder |
| Purity | >99% |
| Solubility | May be dissolved in DMSO (15mg/ml); or Ethanol (3mg/ml). |
| Melting Point | 150-151°C |
| Storage Temp | -20°C, Solutions stored at -20°C are good for 1- 2 months. Store in Tightly Sealed Vial. |
Additional Information
Additional Information
| RTECS | MI5215000 |
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Additional Information
| Certificate of Analysis 1 | T-1052, J1211.pdf |
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| Certificate of Analysis 2 | T-1052, J1134.pdf |
| Certificate of Analysis 3 | T-1052, G1001.pdf |
Additional Information
| Citations | Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3 |
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Additional Information
| No Items Found |
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