Trichostatin A (TSA), is an antifungal antibiotic. It’s cytostatic and differentiating properties are utilized in mammalian cell culture. It is a potent and specific, nonselective HDAC inhibitor, shown to have anti-inflammatory and neuroprotective properties. It inhibits all class I and class II HDAC’s and induces histone acetylation. TSA interacts reversibly with the HDAC catalytic site preventing binding of the substrate. HDACs - Classes I, II, and IV all require a zinc molecule as an essential cofactor in their active site and are inhibited by Zn2+-binding HDAC inhibitor - Trichostatin A (TSA).
Studies have shown antiproliferative and HDAC inhibitory activity of TSA in vitro, in human breast cancer cell lines. its antitumor efficacy and toxicity has been studied in vivo in a carcinogen-induced rat mammary cancer model, which provided evidence for potent dose-dependent antitumor activity of TSA against breast cancer in vitro and in vivo. These studies strongly support HDAC as a molecular target for anticancer therapy in breast cancer.
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|Solubility||May be dissolved in DMSO (15mg/ml); or Ethanol (3mg/ml).|
|Storage Temp||-20°C, Solutions stored at -20°C are good for 1- 2 months. Store in Tightly Sealed Vial.|
|Certificate of Analysis 1||T-1052, J1211.pdf|
|Certificate of Analysis 2||T-1052, J1134.pdf|
|Certificate of Analysis 3||T-1052, G1001.pdf|
|Citations||Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3|
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