Tunicamycin, Tm

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Tunicamycin, Tm

T-1016
  • CAS: 11089-65-9
  • Formula: C39H64N4O16
  • MW: 840.0
  • Appearance: White to off-white Powder
  • Purity: 98.5%

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Tunicamycin is an antibiotic isolated from Streptomyces Iysosuperficus useful in glycoprotein research. This compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts, and viruses. It is an inhibitor of N-linked glycosylation and the formation of N-glycosidic protein-carbohydrate linkages. During protein glycosylation, tunicamycin is noted to inhibit the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

 

 

 

Additional Information

Product #T-1016
CAS #11089-65-9
FormulaC39H64N4O16
MW840.0
AppearanceWhite to off-white Powder
Purity98.5%
SolubilityDMSO: Clear colorless solution at 50 mg/ml ,Ethanol: Clear colorless solution at 5 mg/ml, warm
Melting Point248-250°C
Storage Temp-20°C, Warning! Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.

Additional Information

Merck Index13.6888.2001

Additional Information

HandlingWARNING: VERY TOXIC!

Additional Information

msds 1T-1016, Tunicamycin, SDS, diamond format.pdf
Certificate of Analysis 1T-1016, J1122A.pdf
Certificate of Analysis 2T-1016, J1122.pdf
Certificate of Analysis 3T-1016, J1085.pdf
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