U0126

U-1026
  • CAS: 109522-58-2
  • Formula: C18H16N6S2
  • MW: 380.5
  • Appearance: White Solid
  • Purity: >98%

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Potent and specific inhibitor of MEK1 and MEK2.Blocks the production of inflammatory cytokines and matrix metalloproteinases. Does not inhibit PKA, PKC or CaM KII.

 

Additional Information

Product #U-1026
CAS #109522-58-2
FormulaC18H16N6S2
MW380.5
AppearanceWhite Solid
Purity>98%
SolubilityDMSO (~ 8 mg/ml)
Storage Temp-20°C

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Certificate of Analysis 1U-1026, H1312.pdf
Certificate of Analysis 2U-1026, E1286B.pdf
Certificate of Analysis 3U-1026, E1286A.pdf
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CitationsLi, Bo, et al. "Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity." The Plant Cell (2015): tpc-114.
Lee, Ho-Jae, et al. "Phenotypic modulation of human cardiospheres between stemness and paracrine activity, and implications for combined transplantation in cardiovascular regeneration." Biomaterials 34.38 (2013): 9819-9829.
Teng, Felicia Yu Hsuan, and Bor Luen Tang. "Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults." Molecular and cellular biochemistry 384.1-2 (2013): 7-19.
Meade, Aidan D., et al. "Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes." Faraday discussions 187 (2016): 213-234.
Kim, Hyun-Jung, et al. "The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury." Journal of Pharmacology and Experimental Therapeutics 349.3 (2014): 518-525.
Kim, Namil, et al. "A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells: the importance of activation loop on selectivity." PloS one 9.4 (2014): e91037.
Bar-Lev, Tali H., et al. "Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes." Molecular and cellular endocrinology 415 (2015): 12-23.
Levy, Ran, et al. "Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas." Molecular cancer therapeutics (2010): 1535-7163.
Lu, Dongping, et al. "A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity." Proceedings of the National Academy of Sciences 107.1 (2010): 496-501.
ReferenceGalectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas - Ran Levy, Meital Grafi-Cohen, Zaki Kraiem, et al. Mol. Cancer Ther. Aug 2010. 9: 2208 - 2219.\n
Lu, Dongping, et al. "A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity." Proceedings of the National Academy of Sciences 107.1 (2010): 496-501.
Li, Ming-Yue, et al. "HO-1 plays a central role in NNK-mediated lung carcinogenesis." European Respiratory Journal (2008).
Han, Yoo-Jeong, et al. "Regulation of myosin light chain kinase expression by angiotensin II in hypertension." American journal of hypertension 21.8 (2008): 860-865.
Lu, Dongping, et al. "A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity." Proceedings of the National Academy of Sciences 107.1 (2010): 496-501.
Kim, Hyun-Jung, et al. "The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury." Journal of Pharmacology and Experimental Therapeutics 349.3 (2014): 518-525.

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