Wortmannin

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Wortmannin

W-1022
  • CAS: 19545-26-7
  • Formula: C23H24O8
  • MW: 428.4
  • Appearance: Off-White to Pale Yellow Solid
  • Purity: 98%

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A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase(MAPK) and myosin light-chain kinase (MLCK).Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis, Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES

Additional Information

SynonymsWortmannin, Penicillium wortmanni, KY12420, Antibiotic SL-2052
Product #W-1022
CAS #19545-26-7
Chemical Name(1alpha,11alpha)-11-(Acetyloxy)-1- (methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4- bc)furan-3,7,17-trione
FormulaC23H24O8
MW428.4
AppearanceOff-White to Pale Yellow Solid
Purity98%
SolubilitySoluble in Methanol and DMSO
Melting Point240°C
Storage Temp-20°C
Therapeutic AreaInfectious Diseases
UseWortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase

Additional Information

Merck IndexMerck Index: 13.10110.2001
MDL NumberMFCD00133927
ChemACXX1097086-6
InChIInChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
SMILESCC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C

Additional Information

GHS Pictograms
RTECSCB9641000
UN #'SUN 3462
PACKING GROUPI
HandlingHygroscopic. Store in Tightly Sealed Vial Protect from Light Protect from Moisture.

Additional Information

msds 1W-1022, Wortmannin, SDS, diamond format.pdf
Certificate of Analysis 1W-1022_W-1022,_D1029.pdf
Certificate of Analysis 2W-1022_W-1022,_B1901.pdf
Certificate of Analysis 3W-1022_W-1022,_B1828.pdf
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